Title of article :
Binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor in placentas from normal versus abnormal pregnancy outcomes
Author/Authors :
Allan B. Okey، نويسنده , , John V. Giannone، نويسنده , , William Smart، نويسنده , , Judy M. Y. Wong، نويسنده , , David K. Manchester، نويسنده , , Natalie B. Parker، نويسنده , , M. Mark Feeley، نويسنده , , Donald L. Grant، نويسنده , , Andrew Gilman، نويسنده ,
Abstract :
Binding of [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor was characterized in cytosol from human placentas in which the pregnancy outcome was normal compared with pregnancies in which there was some adverse outcome (premature birth; intrauterine growth retardation; structural abnormality). No significant difference was detected between normal and adverse outcomes in the concentration of AH receptor sites (Bmax) nor in the affinity with which [3H]TCDD bound to the receptor (Kd). Aryl hydrocarbon hydroxylase activity, a CYP1A1 enzyme regulated by the AH receptor, was elevated in placental microsomes from smokers; this elevation was associated with intrauterine growth retardation.
