Murine hepatic p53, RB, and CDK inhibitory protein expression following acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure

This study examined the expression of murine hepatic tumor suppressor and cell cycle inhibitory proteins in response to acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dosing in Balb/c mice. Elevations in expression of p53, retinoblastoma (Rb) protein, p16Ink4, p21Wafl and p27Kipl were observed six days after a single dose of 0.25, 0.5, 1 or 2 μg TCDD/kg. These data suggest that the TCDD-induced inhibition of hepatocyte proliferation in vivo could be attributed to the expression of cell cycle inhibitory proteins.