Author/Authors :
H. J. Kramer، نويسنده , , M. van den Berg، نويسنده , , R-J. Delang، نويسنده , , Lynn L. Brandsma، نويسنده , , J. Dejongh، نويسنده ,
Abstract :
In vitro biotransformation rates of tetrachlorobenzyltoluene (TCBT) isomers 3,3′,4,4′-Cl4-2-Me (TCBT 87), 3,3′,4,4′-Cl4-5-Me (TCBT 88), and 3,3′,4′,5-Cl4-4-Me (TCBT 94) were determined using trout and rat hepatic microsomes. The disappearance of the TCBTs from the in vitro system followed first-order kinetics. The estimated biotransformation constants (k) for the rat ranged from 0.96 to 4.14 h−1. Biotransformation rates for trout microsomes were much lower and ranged from 0.009 to 0.017 h−1.
