Author/Authors :
Cost، Nicholas G نويسنده Department of Urology, Southwestern Medical Center and Children’s Medical Center, Dallas, Texas , , Granberg، Candace F نويسنده Division of Pediatric Urology, Children’s Medical Center of Dallas and University of Texas Southwestern Medical Center, Dallas , , Schlomer، Bruce J نويسنده Division of Pediatric Urology, Children’s Medical Center of Dallas and University of Texas Southwestern Medical Center, Dallas , , Wickiser، Jonathan E نويسنده Division of Pediatric Hematology and Oncology, Children’s Medical Center of Dallas and University of Texas Southwestern Medical Center, Dallas , , Gargollo، Patricio C نويسنده Division of Pediatric Urology, Children’s Medical Center of Dallas and University of Texas Southwestern Medical Center, Dallas , , Baker، Linda A نويسنده Department of Urology, Southwestern Medical Center and Children’s Medical Center, Dallas, Texas , , Rakheja، Dinesh نويسنده Department of Pathology, Children’s Medical Center and University of Texas Southwestern Medical Center, Dallas ,
Abstract :
Purpose: To evaluate the efficacy of needle biopsy for diagnosing Wilms tumor (WT) before chemotherapy.
Materials and Methods: We reviewed our institutional experience with Tru-Cut biopsy of pediatric renal masses in patients who subsequently underwent nephrectomy. We compared biopsy pathology with nephrectomy specimens to determine if biopsy accurately predicted final pathology.
Results: Seven children underwent Tru-Cut renal mass biopsy followed by surgical resection. In 4 patients, the final biopsy pathology was definitively read as WT and in 3 subjects, the pathology was read as WT versus hyperplastic nephrogenic rest. In all 7 patients, the nephrectomy pathology confirmed a diagnosis of WT. There were no complications after biopsy, and no patients have had local or regional recurrence.
Conclusion: In our experience, pre-therapy Tru-Cut biopsy safely provides an adequate specimen for pathologic review in diagnosing WT.
