Author/Authors :
Nasri، Hamid نويسنده , , Nematbakhsh، Mehdi نويسنده , , Ghobadi، Shamin نويسنده Mental health group, Chaharmahal and Bakhtyari Provincial Health Center, Medical School, Shahrekord University of Medical Sciences, Shahrekord , , Ansari، Roya نويسنده PHD Student of Animal Developmental Biology, Kharazmi University, Tehran, Iran Ansari, Roya , Shahinfard، Najmeh نويسنده Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord , , Rafieian-kopaei، Mahmoud نويسنده Department of Pharmacology, Medical Plants Research Center, Shahr-e-kord University of Medical Sciences, Shahr-e-Kord, Iran Rafieian-kopaei, Mahmoud
Abstract :
Background: Gentamicin (GM) is a commonly used aminoglycoside,
however, renal toxicity has limited its usage. This study was designed to
evaluate the curative and protective effects of Zingiber officinale (ginger)
against gentamicin tubular toxicity in rats. The phenolic and flavonoid
components and antioxidant activity of ginger were also evaluated.
Methods: In a preclinical study, 50 male Wistar rats were designated
into 5 groups of 10 and treated as follows: Group I: vehicle. Group II:
200 mg/kg/d of ginger for 3 days then, GM (80 mg/kg) for 7 days.
Group III: 200 mg/kg ginger orally for 3 days, then ginger plus GM for
7 days. Group IV: GM for 7 days. Group V: GM for 10 days. Group VI:
GM for 7 days, then 200 mg/kg ginger orally for 10 days. At the end of
the study, the animals were sacrificed and their kidneys were histologically
evaluated. Results: Ginger could prevent degeneration of the renal
cells and reduce the severity of tubular damage caused by gentamicin.
However, it could not regenerate the GM degeneration.
Conclusions: The results indicate that ginger is effective as a
prophylaxis agent, but has not curative effect.
