Author/Authors :
Shekarchizadeh Esfahani، Parivash نويسنده Department of Physical Education and Sports, Tarbiat Modarres University, Tehran , , Gharakhanlou، Reza نويسنده Department of Physical Education and Sports, Tarbiat Modarres University, Tehran , , Karimian، Jahangir نويسنده Faculty of Management and Medical Information, Isfahan University of Medical Sciences, Isfahan , , Khazaei، Majid نويسنده Department of Physiology, Isfahan University of Medical Sciences, Isfahan , , Feizi، Awat نويسنده Faculty of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan , , Safarzade، Alireza نويسنده Department of Exercise Physiology, University of Mazandaran, Babolsar ,
Abstract :
Background: Asymmetric dimethylarginine (ADMA) has a
predominant role in progression of some cardiovascular diseases,
including diabetes. It interferes with L?arginine in production of
nitric oxide (NO) by inhibition of NO synthase. The purpose of this
study was to evaluate the effect of resistance training on plasma NO and
ADMA concentrations in type 1 diabetic male rats.
Methods: Thirty?six male wistar rats were randomly divided into four
groups: (1) control; (2) diabetic; (3) diabetic trained, and (4) control
trained (n = 9 each). In the trained groups, the animals undertook
one training session per day, 3 days/week, for 4 weeks. At the end of
experiment, blood samples were taken and the concentrations of plasma
glucose, insulin, lipid profile, NO and ADMA concentrations were
determined.
Results: plasma ADMA concentration showed a significant increase in
diabetic rats compare to control group (0.73 ± 0.07 vs. 0.62 ± 0.04 ?mol/l;
P < 0.05). The plasma ADMA level in the trained diabetic and control
were lower than the sedentary groups, although it was not statistically
significant. Plasma NO concentration in diabetic group was lower than
control (P < 0.05). Resistance training significantly increased plasma NO
concentration in diabetic animals (P < 0.05).
Conclusion: Elevated ADMA level in diabetic animals can normalize
during resistance exercise. Reduced ADMA level and increased NO
level following resistance training might improve cardiovascular risk in
diabetic subjects.
