Title of article
Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH3 (edelfosine) and amphotericin B
Author/Authors
G. Patricia Escobar، نويسنده , , Sangeeta Matu، نويسنده , , Cl?udia Marques، نويسنده , , Simon L. Croft، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
7
From page
151
To page
157
Abstract
The sensitivities of both promastigote and amastigote stages of six species of Leishmania, L. donovani, L. major, L. tropica, L. aethiopica, L. mexicana and L. panamensis, were determined in vitro to the phospholipid drugs hexadecylphosphocholine (HPC, miltefosine) and ET-18-OCH3 (edelfosine). In all assays L. donovani was the most sensitive species, with ED50 values in the range of 0.12–1.32 μM against promastigotes and 1.2–4.6 μM against amastigotes. L. major was the least sensitive species in the majority of assays with ED50 values for HPC in the range of 4.8–13.1 μM against promastigotes and for HPC and ET-18-OCH3 in the range of 7.5–37.1 μM against amastigotes. Amphotericin B deoxycholate was used as the standard drug and gave submicromolar ED50 values in all assays; L. mexicana was the least sensitive species to this drug.
Keywords
Alkyl-lysophospholipids , Amphotericin B , ET-18-OCH3 , Leishmania species , Hexadecylphosphocholine
Journal title
Acta Tropica
Serial Year
2002
Journal title
Acta Tropica
Record number
777745
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