Title of article :
Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate
Author/Authors :
Vera Gouvea، نويسنده , , Norma Snellings، نويسنده , , Michael J. Popek، نويسنده , , Charles F. Longer، نويسنده , , Bruce L. Innis، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The complete nucleotide sequence of the Nepali strain TK15/92 of hepatitis E (HEV) was determined. It showed the highest sequence homology with the Burmese B1 strain, but closer evolutionary relatedness to the Indian strains. Difficulties in reverse-transcribing and amplifying the hypervariable region in ORF1 suggested that strong secondary structures might be intrinsically responsible for the high mutational rate observed in this region of the HEV genome.
Keywords :
phylogeny , Hypervariable region , Hepatitis E , HEY , Complete HEY sequence
Journal title :
Virus Research
Journal title :
Virus Research
