Title of article
Non-peptidic inhibitors of neutral endopeptidase 24.11 1. Discovery and optimization of potency
Author/Authors
Stéphane De Lombaert، نويسنده , , Louis Blanchard، نويسنده , , Jenny Tan، نويسنده , , Yumi Sakane، نويسنده , , Carol Berry، نويسنده , , Rajendra D. Ghai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
145
To page
150
Abstract
Although based on a single α-amino acid residue, N-phosphonomethyl-(S)-(4-phenyl)phenylalanine (2) was discovered to produce strong inhibition of the zinc metalloprotease, neutral endopeptidase (NEP 24.11). Structural optimization of this new lead culminated with the design of the phosphonic acid tetrazole 17 (CGS 26303), a non-peptidic and extremely potent NEP inhibitor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787296
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