Author/Authors :
Richard G. Wilde، نويسنده , , Jeffrey T. Billheimer، نويسنده , , Sandra J. Germain، نويسنده , , Peter J. Gillies، نويسنده , , C. Anne Higley، نويسنده , , Hollis S. Kezar III، نويسنده , , Thomas P. Maduskuie، نويسنده , , Edward S. Shimshick، نويسنده , , Ruth R. Wexler، نويسنده ,
Abstract :
A series of compounds bearing heterocyclic substituents were prepared, and evaluated for inhibition of the ACAT enzyme. The heterocyclic groups were compared in terms of in vitro potency against their diarylimidazole analogues. Data for the purposes of QSAR were also collected. Our goal is a systemic ACAT inhibitor, which would be a potential antihypercholesterolemic and antiatherosclerotic agent.
