Title of article
Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist
Author/Authors
S. Richard Baker، نويسنده , , John Goldsworthy، نويسنده , , Raymond C. Harden، نويسنده , , Craig R. Salhoff، نويسنده , , Darryle D. Schoepp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
223
To page
228
Abstract
3,5-Dihydroxyphenylglycine (3,5-DHPG) was resolved using an aminoacylase enzyme in solution, and the enantiomers characterised for ability to stimulate metabotropic glutamate receptor (mGluR) mediated phosphoinositide hydrolysis in rat hippocampus. The mGluR activity resided mainly in the (S) enantiomer, which should thus be a useful tool to further explore mGluR pharmacology and function.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787313
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