Author/Authors :
Gunda I. Georg، نويسنده , , Syed M. Ali Jawaid، نويسنده , , Thomas C. Boge، نويسنده , , Apurba Datta، نويسنده , , Lise Falborg، نويسنده , , Haeil Park، نويسنده , , Marisan Mejillano، نويسنده , , Richard H. Himes، نويسنده ,
Abstract :
The influence of aromatic substitution at the 2-benzoyl moiety of paclitaxel on biological activity was investigated, following the Topliss Operational Scheme. Twelve paclitaxel derivatives were synthesized and evaluated in a microtubule assembly assay and for cytotoxicity against B16 melanoma cells. Most of the analogues were found to possess biological properties similar to paclitaxel.
