Title of article
Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 12. Syntheses and biological activity of structurally novel tetrazole amides
Author/Authors
Patrick M. OʹBrien، نويسنده , , Drago R. Sliskovic، نويسنده , , Maureen K. Anderson، نويسنده , , Richard F. Bousley، نويسنده , , Brian R. Krause، نويسنده , , Richard L. Stanfield، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
289
To page
294
Abstract
The identification of tetrazole benzamide and nicotinamide derivatives as new structural classes of potent ACAT inhibitors is described. The ensuing structure-activity relationship (SAR) studies revealed that retroamide 8c and 7q possesses comparable in vitro potency and efficacy to that of the fatty acid anilide, CI-976 (1).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787325
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