Title of article
Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1′ heteroatom based modifications
Author/Authors
Bruce E. Tomczuk، نويسنده , , Madhusudhan R. Gowravaram، نويسنده , , Jeffrey S. Johnson، نويسنده , , Daniel Delecki، نويسنده , , Ewell R. Cook، نويسنده , , Arup K. Ghose، نويسنده , , Alan M. Mathiowetz، نويسنده , , John C. Spurlino، نويسنده , , Byron Rubin، نويسنده , , Douglas L. Smith، نويسنده , , Tricia Pulvino، نويسنده , , Robert C. Wahl، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
343
To page
348
Abstract
Structure-based drug design (SBDD) and traditional SAR have guided the development of potent and selective hydroxamate inhibitors which contain heteroatom-based modifications of the P1′ group. These inhibitors may help delineate the in vivo roles of specific MMPs in normal and disease states.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787333
Link To Document