Title of article :
Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1′ heteroatom based modifications
Author/Authors :
Bruce E. Tomczuk، نويسنده , , Madhusudhan R. Gowravaram، نويسنده , , Jeffrey S. Johnson، نويسنده , , Daniel Delecki، نويسنده , , Ewell R. Cook، نويسنده , , Arup K. Ghose، نويسنده , , Alan M. Mathiowetz، نويسنده , , John C. Spurlino، نويسنده , , Byron Rubin، نويسنده , , Douglas L. Smith، نويسنده , , Tricia Pulvino، نويسنده , , Robert C. Wahl، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
6
From page :
343
To page :
348
Abstract :
Structure-based drug design (SBDD) and traditional SAR have guided the development of potent and selective hydroxamate inhibitors which contain heteroatom-based modifications of the P1′ group. These inhibitors may help delineate the in vivo roles of specific MMPs in normal and disease states.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1995
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
787333
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=787333
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