Title of article
Synthesis of non-peptide bradykinin B2 receptor antagonists
Author/Authors
Brent D. Douty، نويسنده , , Joseph M. Salvino، نويسنده , , Peter R. Seoane، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
363
To page
366
Abstract
The syntheses of the potent, competitive bradykinin B2 receptor antagonists, 1–3, are described. These compounds represent the three structural classes of B2 receptor antagonists discovered in our program. Compounds 1–3 bind to the human IMR 90 fetal lung fibroblast bradykinin B2 receptor with affinity constants Ki = 3.4 μM, 0.77 μM, and 0.060 μM, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787337
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