Title of article
Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists
Author/Authors
Virendra Kumar Mishra، نويسنده , , Michael D. Alexander، نويسنده , , Malcolm R. Bell، نويسنده , , Michael A. Eissenstat، نويسنده , , Frances M. Casiano، نويسنده , , Susan M. Chippari، نويسنده , , Dean A. Haycock، نويسنده , , Daniel A. Luttinger، نويسنده , , Joan E. Kuster، نويسنده , , Matthew S. Miller، نويسنده , , Joan I. Stevenson، نويسنده , , Susan J. Ward، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
381
To page
386
Abstract
Indence analogs of pravadoline exhibited antinociceptive activity in several animal models. The inhibition of prostaglandin (PG) synthesis in mouse brain microsomes was diminished in these pravadoline analogs, but they were potent in inhibiting electrically stimulated contractions in the mouse vas deferens (MVD) preparations. Binding studies with ligand WIN 55212-2 have aided to demonstrate that the morpholinoalkyl-indene binding site is functionally equivalent with cannabinoid binding site. The antinociceptive activity of the indene derivatives appears to be mediated by increased affinity for the cannabinoid receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787341
Link To Document