Title of article
Novel trityl linked drug immunoconjugates for cancer therapy
Author/Authors
Vinod F. Patel، نويسنده , , Julie N. Hardin، نويسنده , , James J. Starling، نويسنده , , John M. Mastro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
507
To page
512
Abstract
Trityl linkers were utilized in the preparation of acid labile nucleoside monoclonal antibody conjugates, COL1-N6-Trityl-207702 (1a-f). Conjugation led to high levels of drug incorporation into the MoAb with retention of good immunoreactivity. A strong correlation was found between the cytotoxicity of the constructs and substituents R and R′ on the aromatic rings of the trityl linker.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787363
Link To Document