Title of article
Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides containing extended alkyl residues At P1ʹ
Author/Authors
Craig K. Esser، نويسنده , , Ihor E. Kopka، نويسنده , , Philippe L. Durette، نويسنده , , Richard K. Harrison، نويسنده , , Lisa M. Niedzwiecki، نويسنده , , Maria Izquierdo-Martin، نويسنده , , Ross L. Stein، نويسنده , , William K. Hagmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
539
To page
542
Abstract
A series of N-carboxyalkyl peptides were prepared to test their inhibitory activity against human stromelysin (MMP-3), collagenase (MMP-1), and gelatinase A (MMP-2). Linear alkyl and ω-aminoalkyl residues were employed as replacements for a phenethyl group yielding inhibitors with in vitro activities comparable to their corresponding aromatic analogs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787368
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