Title of article :
Influence of the absolute configuration at C-4 in the binding of d-myoinositol 1,4,5 trisphosphate analogues to IP3 receptor
Author/Authors :
E. Poirot، نويسنده , , H. Bourdon، نويسنده , , F. Chrétien، نويسنده , , Y. Chapleur، نويسنده , , B. Berthon، نويسنده , , M. Hilly، نويسنده , , J.-P. Mauger، نويسنده , , G. Guillon، نويسنده ,
Abstract :
Biomimetic syntheses of enantiomerically pure 3-deoxy-d-muco- and d-myo-inositol-1,4,5 trisphosphate from d-glucose are described. Preliminary biological studies show a dramatic influence of the stereochemistry at C-4 on the binding to IP3 receptor.
