Author/Authors :
John X. He، نويسنده , , Wayne L. Cody، نويسنده , , Michael A. Flynn، نويسنده , , Kathleen M. Welch، نويسنده , , Elwood E. Reynolds، نويسنده , , Annette M. Doherty، نويسنده ,
Abstract :
RES-701-1 is a cyclic peptide isolated from Streptomyces sp. RES-701 that has been reported to selectively inhibit the ETB receptor subtype with an IC50 of 10 nM. Independently, we have prepared RES-701-1 and found that it only possesses micromolar affinity for either the human ETA or ETB receptors. The solid/solution phase synthesis is amenable to the multigram scale.
