• Title of article

    Tricyclic cephems as inhibitors of human leukocyte elastase. Furo[3,4-c]cepham sulfones

  • Author/Authors

    Marco Alpegiani، نويسنده , , Pierluigi Bissolino، نويسنده , , Riccardo Corigli، نويسنده , , Vincenzo Rizzo، نويسنده , , Ettore Perrone، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1995
  • Pages
    4
  • From page
    687
  • To page
    690
  • Abstract
    Furo[3,4-c]cepham sulfones were efficiently obtained from 1,1-dioxo-3-methylcephem-4-ketones. Cyclization improved at one time stability of the β-lactam towards hydrolytic cleavage (pH 7.4) and reactivity (second-order inhibition rate constant kon) towards human leukocyte elastase.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1995
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    787397