Title of article
Tricyclic cephems as inhibitors of human leukocyte elastase. thieno[3,4-c]cepham sulfones and pyrrolo[3,4-c]cepham sulfones
Author/Authors
Marco Alpegiani، نويسنده , , Pierluigi Bissolino، نويسنده , , Riccardo Corigli، نويسنده , , Vincenzo Rizzo، نويسنده , , Ettore Perrone، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
691
To page
694
Abstract
Thieno- and pyrrolo[3,4-c]cepham sulfones were synthesized and compared to their furo analogs for activity as human leukocyte elastase inhibitors. Pyrrolo derivatives, especially when N-alkylated, combined excellent hydrolytic stability with remarkable inhibitory activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787398
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