Dual metalloprotease inhibitors.v. Utilization of bicyclic azepinonethiazolidines and azepinonetetrahydrothiazines in constrained peptidomimetics of mercaptoacyl dipeptides
Author/Authors :
William A. Slusarchyk، نويسنده , , Jeffrey A. Robl، نويسنده , , Prakash C. Taunk، نويسنده , , Magdi M. Assad، نويسنده , , J. Eileen Bird، نويسنده , , John DiMarco، نويسنده , , Yolanda Pan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
6
From page :
753
To page :
758
Abstract :
Incorporation of mercaptoacetyl or mercaptopropanoyl groups into azepinonethiazolidine and azepinonetetrahydrothiazine carboxylic acids provided conformationally restricted peptidomimetics of Ala-Pro exhibiting potent dual activity in vitro versus ACE and NEP.
