Title of article
Design, synthesis and biological activity of some tetraamines related to methoctramine and 4-DAMP
Author/Authors
Carlo Melchiorre، نويسنده , , Anna Minarini، نويسنده , , Santi Spampinato، نويسنده , , Vincenzo Tumiatti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
785
To page
790
Abstract
Three novel tetraamines (1–3) related to methoctramine were designed, and their biological profiles at muscarinic receptor subtypes were assessed by binding assays. It turned out that the constrained analogue spirotramine (3, FC 15–94) of 4-DAMP has an affinity profile better than that of pirenzepine owing to a high affinity for muscarinic M1 receptors and a significantly lower affinity for the M2, M3 and M4 subtypes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787415
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