Author/Authors :
Tetsuro Fujita، نويسنده , , Masahiko Yoneta، نويسنده , , Ryoji Hirose، نويسنده , , Shigeo Sasaki، نويسنده , , Kenichiro Inoue، نويسنده , , Masatoshi Kiuchi، نويسنده , , Susumu Hirase، نويسنده , , Kunitomo Adachi، نويسنده , , Masafumi Arita، نويسنده , , Kenji Chiba، نويسنده ,
Abstract :
ISP-I (myriocin, thermozymocidin) was structurally simplified to give 2-amino-2-alkyl-1,3-propanediols that were also potent immunosuppressants. Among the series, 2-amino-2-pentadecyl-1,3-propanediol most actively prolonged rat skin allograft survival and was more effective than ciclosporin.
