The in vitro effects of three lysosomotropic detergents against three human tumor cell lines

Three lysosomotropic detergents, N-dodecylimidazole (NDI) 1, and two new analogues, serine dodecylamide (SDA) 2 and O-methyl serine dodecylamide (MSD) 3, were tested against three human tumor cell lines in vitro: HCT116, RCA and MCF-7. All three demonstrated dose-related cytotoxicity which, except for a few cases, was also dependent on incubation time, and visually resembled cell death by apoptosis.