Preparation and biological evaluation of β-Trifluoromethyl-α,β-unsaturated carbonyl compounds

β-Trifluoromethyl-α,β-unsaturated carbonyl compounds derived from (E)-3-(trifluoromethyl)acrylic acid 1 and D-(−)-pantoic acid lactone 3 and/or L-mannitol 5 were found to possess in vitro interleukin-2 antiproducing effect