Title of article
Selective inhibition of the tyrosine kinase pp60src by analogs of 5,10-dihydropyrimido[4,5-b]quinolin-4(1H)-one
Author/Authors
Robert L. Dow، نويسنده , , Bruce M. Bechle، نويسنده , , Thomas T. Chou، نويسنده , , Colin Goddard، نويسنده , , Eric R. Larson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1007
To page
1010
Abstract
7,8-Dimethoxy-5,10-dihydropyrimido[4,5-b]quinolin-4(1H)-one (1b) has been discovered to be a potent and selective inhibitor of the tyrosine-specific kinase activity associated with pp60c-src. Mole of inhibition studies reveal that this agent inhibits in a pure-mixed-noncompetitive mode with respect to nucleotide co-factor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787459
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