Title of article
α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II)
Author/Authors
Thomas F. Walsh، نويسنده , , Kenneth J. Fitch، نويسنده , , Raymond S. L. Chang، نويسنده , , Kristie A. Faust، نويسنده , , Tsing-Bau Chen، نويسنده , , Salah D. Kivlighn، نويسنده , , Gloria J. Zingaro، نويسنده , , Victor J. Lotti، نويسنده , , Peter K. S. Siegl، نويسنده , , Arthur A. Patchett، نويسنده , , William J. Greenlee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1151
To page
1154
Abstract
Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT1-selective AII antagonists. Substitution in the central aromatic ring significantly increases AT2 receptor affinity such that the n-propyl derivative 7g displayed low nanomolar potency at both AT1 and AT2 receptor subtypes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787486
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