Author/Authors :
Thomas F. Walsh، نويسنده , , Kenneth J. Fitch، نويسنده , , Raymond S. L. Chang، نويسنده , , Kristie A. Faust، نويسنده , , Tsing-Bau Chen، نويسنده , , Salah D. Kivlighn، نويسنده , , Gloria J. Zingaro، نويسنده , , Victor J. Lotti، نويسنده , , Peter K. S. Siegl، نويسنده , , Arthur A. Patchett، نويسنده , , William J. Greenlee، نويسنده ,
Abstract :
Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT1-selective AII antagonists. Substitution in the central aromatic ring significantly increases AT2 receptor affinity such that the n-propyl derivative 7g displayed low nanomolar potency at both AT1 and AT2 receptor subtypes.
