Title of article
Stereochemical differentiation of anticonvulsant and antihypertensive effects in 4-(fluorobenzoylamino)-benzopyrans
Author/Authors
Thomas P. Blackburn، نويسنده , , Robin E. Buckingham، نويسنده , , Wai N. Chan، نويسنده , , John M. Evans، نويسنده , , Michael S. Hadley، نويسنده , , Mervyn Thompson، نويسنده , , Neil Upton، نويسنده , , Tania O. Stean، نويسنده , , Geoffrey Stemp، نويسنده , , Antonio K. Vong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1163
To page
1166
Abstract
Replacement of the 2-pyrrolidinone group of cromakalim 1 by the fluorobenzoylamino group has introduced anticonvulsant activity. It is particularly noteworthy that this activity is found predominantly in the 3R,4S enantiomeric series. In contrast, antihypertensive activity is restricted to the 3S,4R enantiomeric series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787489
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