Title of article
A single precursor approach to new DNA cleaving and crosslinking agents
Author/Authors
David J. Jebaratnam، نويسنده , , Dev P. Arya، نويسنده , , Yih-Hang Chen، نويسنده , , S. Kugabalasooriar، نويسنده , , Duc Vo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1191
To page
1196
Abstract
It is demonstrated that aryl diamine 1, designed after a d(A•T) specific minor groove binding agent, can serve as a precursor for the synthesis of two DNA cleaving (bisdiazonium 2 and bisazoester 5) and one crosslinking (bisazide 7) agents and, to this end, the present strategy is introduced as a convergent approach for the development of DNA targeted anticancer drugs.
Article Outline
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787495
Link To Document