An attempt to synthesize prostanoid thromboxane A2 antagonists with an additional prostacyclin like quality

The preparation and biological characterisation of prostanoid TXA2(TP)-antagonists which are modified at position 9 to add a PGI2-like quality is described. Although we obtained highly potent TP-receptor antagonists, the synthesized compounds do not inhibit the ADP induced platelet aggregation and thus do not have any PGI2(IP)-mimetic properties.