Title of article :
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.
Author/Authors :
A. Marfat، نويسنده , , R. Chambers، نويسنده , , J. Cheng، نويسنده , , K. Cooper، نويسنده , , D. Damon، نويسنده , , J. Delehunt، نويسنده , , J. Eggler، نويسنده , , H. Masamune، نويسنده , , Cathy L. Melvin، نويسنده , , J. Watson، نويسنده ,
Abstract :
The combination of key structural pharmacophores found in known leukotriene D4 (LTD4) receptor antagonists with those of potent platelet activating factor (PAF) receptor antagonist UK-74,505 has led to the synthesis of hybrid compounds CP-96,021 and CP-96,486. These compounds represent the first known balanced, combined and orally active LTD4/PAF receptor antagonists.
