Title of article
Inhibition of interleukin-1β converting enzyme by N-Acyl-aspartic acid ketones
Author/Authors
Adnan M. M. Mjalli، نويسنده , , Kevin T. Chapman، نويسنده , , Justin J. Zhao، نويسنده , , Nancy A. Thornberry، نويسنده , , Erin P. Peterson، نويسنده , , Malcolm MacCoss، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1405
To page
1408
Abstract
N-Acyl aspartic acid ketones (3a-3n) were prepared from the corresponding bromomethyl ketone. The inhibition of interleukin-1β converting enzyme (ICE) by these single amino acid ketones is reported. The best compound had Ki of 3.5 μM versus ICE.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787532
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