Author/Authors :
Adnan M. M. Mjalli، نويسنده , , Justin J. Zhao، نويسنده , , Kevin T. Chapman، نويسنده , , Nancy A. Thornberry، نويسنده , , Erin P. Peterson، نويسنده , , Malcolm MacCoss، نويسنده , , William K. Hagmann، نويسنده ,
Abstract :
The synthesis of N-allyloxy-aspartyl aryloxymethyl ketones and their evaluation as inhibitors of interleukin-1β converting enzyme (ICE) are described. 3-Substituted 2-naphthyloxymethyl ketones were found to have Kiʹs of 90–500 nM. The SAR suggests that the substituents on the aryloxy group may have a specific binding interaction in the active site of ICE.
