Synthesis of potential γ-lactam antibiotics

Synthesis and biological testing of new 2-[4-(2-(2-amino-4-thiazolyl)-(Z)-2-(methoxyimino) acetylamino)-3-oxo-2-isoxazolidinyl]-2-aryloxy acetic acids analogs of lactivicin are described. The new products were obtained by addition of cycloserine derivatives on t-butyl 2-aryloxy-2-bromo acetate. Substitution on the aryloxy group modifies its leaving ability and allows different levels of activation of the γ-lactam ring.