Author/Authors :
Haruyuki Chaki، نويسنده , , Haruko Yamabe، نويسنده , , Mamoru Sugano، نويسنده , , Shuji Morita، نويسنده , , Tomoko Bessho، نويسنده , , Reiko Tabata، نويسنده , , Ken-ichi Saito، نويسنده , , Mitsuo Egawa، نويسنده , , Akihiro Tobe، نويسنده , , Yasuhiro Morinaka، نويسنده ,
Abstract :
The synthesis of 4-acylaminopyridine derivatives and their high affinity choline uptake improvement activities are described. N-propylcarbonyltetrahydroaminoacridine (1) was selected as a lead compound. Modification of its ring structure and acyl moiety led some active compounds. Among them, 9d (MKC-231) showed the highest activity. This compound is expected to be a unique medicine for Alzheimerʹs disease.
