Synthesis of neoeudistomin analogs—As potential filaricides

Utilizing Pictet-spengler cyclisation, derivatives of neoeudistomin, 1-(furan-2-yl/thien-2-/3-yl/pyrrol-2-yl)-9H-pyrido[3,4-b]indoles have been synthesized. These compounds exhibited promising filaricidal activity, in vivo against Litomosoides carinii and Acanthocheilonema viteae in rodents.