Author/Authors :
Douglas G. Batt، نويسنده , , Robert A. Copeland، نويسنده , , Randine L. Dowling، نويسنده , , Tracy L. Gardner، نويسنده , , Elizabeth A. Jones، نويسنده , , Michael J. Orwat، نويسنده , , Donald J. Pinto، نويسنده , , William J. Pitts، نويسنده , , Ronald L. Magolda، نويسنده , , Bruce D. Jaffee، نويسنده ,
Abstract :
The immunosuppressive structure-activity relationships of substituted cinchoninic acid derivatives related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to benzo-ring substitution, replacement of the benzo-ring by heterocycles, and variation in the 2-biphenyl, 3-methyl, and 4-carboxy groups.
