Author/Authors :
Nitya G. Kundu، نويسنده , , Jyan S. Mahanty، نويسنده , , C. Paul Spears، نويسنده , , Graciela Andrei، نويسنده , , Robert Snoeck، نويسنده , , J. Balzarini، نويسنده , , Erik De Clercq، نويسنده ,
Abstract :
5-Iodo-2′-deoxyuridine was converted to (E)-5-(2-acylvinyl)-2′-deoxyuridines by palladium-catalyzed reactions in excellent yields. Compound 2 [(E)-5-(2-benzoylvinyl)-2′-deoxyuridine] had a weak activity against tumor cell lines. In contrast to BVDU, compound 2 and its (E)-5-[2-(p-methoxybenzoyl)vinyl] counterpart (compound 3) were inactive against HSV-1 and VZV.
