Title of article
Symmetry-based HIV Protease inhibitors: rational design of 2-methylbenzamides as novel P2/P2′ ligands
Author/Authors
Ramnarayan S. Randad، نويسنده , , Lucyna Lubkowska، نويسنده , , T. Narayana Bhat، نويسنده , , Sanjeev Munshi، نويسنده , , Sergei V. Gulnik، نويسنده , , Betty Yu، نويسنده , , John W. Erickson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1707
To page
1712
Abstract
Readily accessible, non-peptidic, achiral 2-methylbenzamides were designed to serve as P2/P2′ ligands for symmetry-based inhibitors of HIV-1 Protease. Introduction of 3-hydroxy substituent provided a potent inhibitor 7 (Ki = 0.8 nM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787588
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