Synthesis of racemic 2-phosphonomethyl-1,3-dioxolane nucleoside analogues as potential antiviral agents

2-Phosphonomethyl-1,3-dioxolane nucleosides containing appropriately linked pyrimidine and purine bases at C-4 position were prepared as biomimetic analogues of antiviral 2′,3′-dideoxynucleoside monophosphates. The key coupling intermediate 10 was prepared by a cyclocondensation of diethylacetal 6 and diol 7 followed by hydrolysis and lead tetra-acetate oxidative decarboxylation.