Title of article
Hydroxylation at C-3′ of doxorubicin alters the selected phenotype of cellular drug resistance
Author/Authors
Leonard Lothstein، نويسنده , , Trevor W. Sweatman، نويسنده , , Waldemar Priebe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1807
To page
1812
Abstract
Hydroxylation at C-3′ of doxorubicin (DOX) yields the uncharged congener hydroxyrubicin, which circumvents P-glycoprotein-mediated drug resistance without loss of topoisomerase II inhibitory activity. Hydroxyrubicin-resistant cells exhibit a phenotype that is uniquely different from DOX resistance by expressing non-functional P-glycoprotein and hypersensitivity to anti-mitotic drugs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787604
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