4-(2-pyridyl)-2,2-dimethylnaphthalen-1-ones as new potassium channel activators with increased airways selectivity

A new series of 4-(2-pyridyl)-2,2-dimethylnaphthalen-1-one potassium channel activators has been prepared and their in vitro1 relaxant activities in isolated rat portal vein and guinea-pig tracheal spirals as well as their hypotensive and bronchodilatory effects have been evaluated. Oxidation of the pyridyl nitrogen atom and a double bond between positions 3 and 4 provide compounds with some degree of airways selectivity.