Annohexocin, a novel mono-THF acetogenin with six hydroxyls, from Annona muricata (Annonaceae)

A novel bioactive acetogenin, annohexocin (1), was isolated from the leaves of the sour sop (or guanabana) tree, Annona muricata (Annonaceae). Compound 1 is a C-35 mono-tetrahydrofuran (THF) acetogenin having six OH groups, and its structure has been elucidated by spectroscopic analyses. Compound 1 is the first Annonaceous acetogenin to be reported in which six OH groups include a 1,3,5 triol. Compound 1 was isolated by following brine shrimp lethality, and it showed significant inhibitory effects among six human tumor cell lines.