Title of article :
An efficient synthesis and biological activities of 19-nor-17β-hydroxy-17α-trifluoromethyl-Δ4-estren-3-one and its analogs
Author/Authors :
Zhong-Qi Wang، نويسنده , , Shou-Fu Lu، نويسنده , , Lin Chao and، نويسنده , , Chuan-Jun Yang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Abstract :
19-Nor-17β-hydroxy-17α-trifluoromethyl-Δ4-estren-3-one 6 and its analogs 7 and 8 have been synthesized in total yields of 82%, 54% and 27%, respectively, using Me3SiCF3 as a trifluoromethylating agent. The three compounds showed high affinity for rat uterus PRc.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
