Author/Authors :
John A. Lowe III، نويسنده , , Susan E. Drozda، نويسنده , , Stafford McLean، نويسنده , , Dianne K. Bryce، نويسنده , , Rosemary T. Crawford، نويسنده , , Stevin Zorn، نويسنده , , Jean Morrone، نويسنده , , Troy A. Appleton، نويسنده , , Franco Lombardo، نويسنده ,
Abstract :
A series of 5-substituted-3-ureidobenzazepin-2-ones bearing ioizable functionality was synthesized as potential cholecystokinin-B (CCK-B) receptor antagonists. SAR of this series of compounds demonstrated the optimal combination of a carboxylic acid and 5-cyclohexyl group, providing the high affinity (CCK-B IC50 = 0.10 nM), water soluble CCK-B antagonist 2.
