Title of article :
Chemoenzymatic synthesis and incorporation of -2-quinoxalylalanine into a tandem β-turn peptide motif
Author/Authors :
Xiaofen Huang، نويسنده , , Eric C. Long، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Abstract :
-2-Quinoxalylalanine was synthesized chemoenzymatically and incorporated through solid-phase peptide synthesis at both termini of one repeat unit of the carboxy-terminal domain (CTD) of RNA polymerase II. The resulting structure closely resembles members of the quinoxaline class of bis-intercalating antitumor antibiotics and may eventually assist in probing the DNA binding mechanism of the CTD.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters