Author/Authors :
Janice R. Sufrin، نويسنده , , Arthur J. Spiess، نويسنده , , Canio J. Marasco Jr.، نويسنده , , Simon L. Croft، نويسنده , , Diane Snowdon، نويسنده , , Vanessa Yardley، نويسنده , , Cyrus J. Bacchi، نويسنده ,
Abstract :
Synthesis of purine 2′,3′-acyclonucleosides has been improved by using methanol as solvent for sequential oxidation/reduction reactions on periodate- and borohydride-bound resins. Several O-acetylated derivatives of acyclic analogs prepared by this procedure have significant antitrypanosomal activity in vitro.
