Title of article :
Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase
Author/Authors :
Yoshikazu Iwasawa، نويسنده , , Masahiro Hayashi، نويسنده , , Takashi Nomoto، نويسنده , , Jun Shibata، نويسنده , , Morihiro Mitsuya، نويسنده , , Kenj Hirota، نويسنده , , Mari Yonemoto، نويسنده , , Toshio Kamei، نويسنده , , Keiko Miura، نويسنده , , Koji Tomimoto، نويسنده ,
Abstract :
A new structural class of squalene synthase (SQS) inhibitor, J-104,118, was developed by chemical modification of L-592,901. The absolute configuration of J-104,118 was determined by X-ray crystal analysis. An oral dose of J-104,118 potently inhibited cholesterol synthesis in mice.
